There are several reasons why the standard X mouse cursors are hard to track for some people:
In all cases it might help to use enlarged mouse cursors. Ideally this job should be done by a single X program that automatically enlarges every mouse cursor.
To my knowledge there is no simple way to write a utility like this, because the X protocol has no provision to query mouse cursors. For more details see section Technical discussion below.
If we aim for a less general goal, though, something can be done:
There is a set of standard mouse cursors that can be found in the cursor font (try
xfd -fn cursor to look at it). Most programs use these mouse cursors and the key idea is to replace the standard cursor font with an enlarged version.